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Patients with the autoimmune disorder lupus erythematosus (SLE) exhibit multiple immune system defects. In this issue of the Journal of Clinical Investigation, Elizabeth Jury and colleagues at University College London reveal that T cells isolated f
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Treatment of patients with type 2 diabetes (T2D) with the drug metformin greatly reduces diabetic complications and mortality. Unfortunately, many patients on metformin therapy become hyperglycemic, which exacerbates insulin resistance and reduces β
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Various muscular diseases are associated with changes in the elasticity of the protein titin, but whether these changes are a cause or an effect of disease has been unclear. A study in The Journal of General Physiology helps solve this "chicken or t
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Kinesins are motor proteins that "walk" along microtubules and transport various cargoes throughout the cell. A study in The Journal of Cell Biology uncovers an unexpected role for one kinesin in the pathway that regulates cholesterol levels in the
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The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen, and long-term exposure to UVR can lead to skin cancer and premature aging of the skin. To develop better methods of protection from the sun, we need to
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Women who use postmenopausal hormone replacement therapy (HRT) may be at increased risk of acute pancreatitis, found a new study in CMAJ (Canadian Medical Association Journal).Acute pancreatitis, a sudden inflammation of the pancreas, has symptoms t
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Drugs used to treat HIV penetrate poorly into lymphatic tissues where most HIV replication takes place and there is persistent low-level virus replication in these tissues according to research from the University of Minnesota and University of Nebr
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How do you prevent and treat the common cold? Handwashing and zinc may be best for prevention whereas acetaminophen, ibuprofen and perhaps antihistamine-decongestant combinations are the recommended treatments, according to a review in CMAJ (Canadia
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