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Intracellular hypoxia has been linked to genetic instability, tumour progression and poor prognosis. Little is known about the effect of hypoxia on DNA-dsb sensing and repair. We tested whether the sensing of DNA-dsbs and chromatin biology is decrea
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Children and teenagers are keen internet users - 12 to 15-year-olds spend at least three hours a day on screen - but they are not always aware of the dangers of certain sites or content: not only material containing child pornography or violence but
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One of the real problems for patients treated with radiotherapy to sites including the salivary glands is xerostomia, or dry mouth syndrome. This can severely affect cancer patients' quality of life. Current treatments and prevention techniques for
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In adopting an own-initiative report on the mid-term review of the European Environment and Health Action Plan 2004-2010, the European Parliament acknowledges the efforts made by the Commission since the action plan was launched in 2004. It consider
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Evidence shows that pre-treatment tumour hypoxia correlates with poor radiotherapy outcome. Using an hypoxia marker, pimonidazole, it has been shown that biochemical hypoxia in tumours before treatment correlates with local control after radiotherap
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Intensity modulated arc therapy offers great advantages by delivering a fast and highly conformal treatment. However, moving targets represent a major challenge. By monitoring a moving target it is possible to make the beam follow the motion, shaped
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High precision radiotherapy requires accurate tumour localisation for patient positioning just prior to treatment. Respiratory motion induces artifacts in cone-beam (CB) CT images of the thorax and upper abdomen which can prevent an accurate localis
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Organ movement remains the biggest challenge in prostate cancer treatment. Computerised tomography (CT scans) provide incomplete information about movement of the prostate. To address this problem, a statistical model of motion as been created using
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