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The integral membrane protein Caveolin-1 forms small invaginations of the plasma membrane, so-called caveolae, for serving in endo-exocytosis and is involved in regulating signaling from integrins and receptor-tyrosine kinases. Both, integrins and r
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Although suboptimal postoperative pain control is associated with cardiovascular, respiratory and gastrointestinal complications, many multimodal regimens for analgesia following major colorectal laparotomy provide inadequate pain relief. Continuous
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After external radiotherapy for prostate cancer, patients can suffer from long-term urinary problems, including incontinence and obstruction. Many studies have investigated the relationship between urinary problems and the radiation dose the bladder
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Intracellular hypoxia has been linked to genetic instability, tumour progression and poor prognosis. Little is known about the effect of hypoxia on DNA-dsb sensing and repair. We tested whether the sensing of DNA-dsbs and chromatin biology is decrea
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Children and teenagers are keen internet users - 12 to 15-year-olds spend at least three hours a day on screen - but they are not always aware of the dangers of certain sites or content: not only material containing child pornography or violence but
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One of the real problems for patients treated with radiotherapy to sites including the salivary glands is xerostomia, or dry mouth syndrome. This can severely affect cancer patients' quality of life. Current treatments and prevention techniques for
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In adopting an own-initiative report on the mid-term review of the European Environment and Health Action Plan 2004-2010, the European Parliament acknowledges the efforts made by the Commission since the action plan was launched in 2004. It consider
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Evidence shows that pre-treatment tumour hypoxia correlates with poor radiotherapy outcome. Using an hypoxia marker, pimonidazole, it has been shown that biochemical hypoxia in tumours before treatment correlates with local control after radiotherap
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