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Patients with inflammatory diseases such as rheumatoid arthritis now have many more treatment options than in the past, including biologic disease-modifying antirheumatic drugs (DMARDs). These drugs, derived by modifying substances found in humans o
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In this week's PLoS Biology, authors Mark Siegal and Sasha Levy identify genes that prevent physical traits from being affected by environmental changes.
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The elucidation of principles governing evolution of gene regulatory sequence is critical to the study of metazoan diversification. The authors are therefore exploring the structure and organizational constraints of regulatory sequences by studyi
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Drosophila clock neurons are self-sustaining cellular oscillators that rely on negative transcriptional feedback to keep circadian time. Proper regulation of organismal rhythms of physiology and behavior requires coordination of the oscillations
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An over-the-counter vitamin in high doses prevented memory loss in mice with Alzheimer's disease, and UC Irvine scientists now are conducting a clinical trial to determine its effect in humans. Nicotinamide, a form of vitamin B3, lowered levels o
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Destruction Of Joints By Arthritis: Genetic Disorder Sheds Light On Enzyme's Role In Bone Metabolism
Pycnodysostosis, a condition from which the painter Henri de Toulouse-Lautrec suffered, is a genetic disease characterized by short stature. This rare disease, surprisingly, provides a window into how joints are destroyed by arthritis.
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The damaging effects of smoking and smoke exposure can be seen at any age. Pediatricians have even noted these negative effects in various stages of infant development. The consequences of maternal smoke exposure during pregnancy can range from hi
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Increasing quantities of medical supplies are being provided by foreign governments to save lives in eastern Democratic Republic of Congo, but the World Health Organization (WHO) is calling for more support to meet urgent health needs.
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