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Acute rejection of a transplanted organ by the recipient is mediated by an inflammatory immune response. Despite current immunosuppressive therapies, organ rejection remains problematic. In this issue of the Journal of Clinical Investigation, Craig
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Spinal muscle atrophy (SMA) is a devastating disease that is characterized by loss of motor neuron function and subsequent muscle weakness and atrophy. The disease results from deletion of survival of motor neuron 1 (SMN1) and SMN protein deficiency
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Patients with osteogenesis imperfecta (OI) are prone to bone fracture and skeletal deformity, and treatment options for these patients are severely limited. In this issue of the Journal of Clinical Investigation, Eric Orwoll and colleagues at Oregon
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Patients with the autoimmune disorder lupus erythematosus (SLE) exhibit multiple immune system defects. In this issue of the Journal of Clinical Investigation, Elizabeth Jury and colleagues at University College London reveal that T cells isolated f
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Treatment of patients with type 2 diabetes (T2D) with the drug metformin greatly reduces diabetic complications and mortality. Unfortunately, many patients on metformin therapy become hyperglycemic, which exacerbates insulin resistance and reduces β
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Various muscular diseases are associated with changes in the elasticity of the protein titin, but whether these changes are a cause or an effect of disease has been unclear. A study in The Journal of General Physiology helps solve this "chicken or t
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Kinesins are motor proteins that "walk" along microtubules and transport various cargoes throughout the cell. A study in The Journal of Cell Biology uncovers an unexpected role for one kinesin in the pathway that regulates cholesterol levels in the
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The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen, and long-term exposure to UVR can lead to skin cancer and premature aging of the skin. To develop better methods of protection from the sun, we need to
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