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Health Care International - Dysfunctional TGF-beta signaling contributes to Loeys-Dietz syndrome-associated aortic aneurysm
Patients with the connective tissue disorder Loeys-Dietz syndrome (LDS) are at high risk for aortic aneurysm. LDS results in the presence of missense mutations within either of the genes encoding receptors for TGF-β. LDS-associated mutations are pre
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